Spectrum of Resistance Mechanisms to ALK TKIs in NSCLC: Largest Single-Center Experience from India

Spectrum of Resistance Mechanisms to ALK TKIs in NSCLC: Largest Single-Center Experience from India

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Introduction Close Contact Conventional Harness Anaplastic lymphoma kinase (ALK) rearranged non-small cell lung carcinoma (NSCLC) has emerged as a distinct entity with growing number of potent ALK tyrosine kinase inhibitors (TKIs).Despite showing durable responses and promising survival rates, resistance to these ensue.This is the largest series of repeat biopsies from Optical Triggers patients of ALK-positive NSCLC progressing on ALK-directed therapy from this part of the world.

Using a combinatorial approach of genomics and histology, we describe the spectrum of various resistance mechanisms encountered.